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Found 4 Enz. Inhib. hit(s) with Target = 'Wee1-like protein kinase' and Ligand = 'BDBM50043654'
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043654(CHEMBL3355539)
Affinity DataKi: <1nMAssay Description:Inhibition of GST-tagged human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043654(CHEMBL3355539)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to wild type N-terminal GST-tagged human WEE1 catalytic domain (215 to 646 residues) expressed in baculovirus expression system meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043654(CHEMBL3355539)
Affinity DataEC50:  60nMAssay Description:Inhibition of WEE1 in human NCI-H1299 cells assessed as reduction in Cdc2 phosphorylation at Tyr15 residue measured after 6 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043654(CHEMBL3355539)
Affinity DataEC50:  60nMAssay Description:Inhibition of human Weel1 in human NCI-H1299 cells assessed as phosphorylation of Cdk1 after overnight incubation by ELISA PD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed