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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM173106'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM173106
PNG
(US9096589, 2-[2-(1-Isobutyl-4-thiophen-2-yl-1H-imi...)
Show SMILES CC(C)Cn1cc(nc1CCc1cn2c(C)cc(C)nc2n1)-c1cccs1
Show InChI InChI=1S/C21H25N5S/c1-14(2)11-25-13-18(19-6-5-9-27-19)24-20(25)8-7-17-12-26-16(4)10-15(3)22-21(26)23-17/h5-6,9-10,12-14H,7-8,11H2,1-4H3
PDB
MMDB

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Similars

US Patent
n/an/a 12n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair