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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'p110alpha-iSH2 p85alpha Complex' and Ligand = 'BDBM207504'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p110alpha-iSH2 p85alpha Complex


(Homo sapiens (Human))
BDBM207504
PNG
(US9260439, 388)
Show SMILES C[C@@]1(CCN(C1)C(=O)c1ncc[nH]1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1
Show InChI InChI=1S/C23H28N10O2/c1-23(3-7-32(14-23)20(34)18-25-4-5-26-18)33-6-2-16-17(15-12-27-21(24)28-13-15)29-22(30-19(16)33)31-8-10-35-11-9-31/h4-5,12-13H,2-3,6-11,14H2,1H3,(H,25,26)(H2,24,27,28)/t23-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
<0.0180n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
PI3KA_Act: Genes encoding for full length p110alpha and p85alpha nSH-iSH2=niSH2 (p85a aminoacids 322-600) subunits of PI3Kalpha complex were subclone...


US Patent US9260439 (2016)


BindingDB Entry DOI: 10.7270/Q2VH5MPV
More data for this
Ligand-Target Pair