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Found 3 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 2A6' and Monomerid = 12343
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM12343(CHEMBL369285 | US8609708, 9 | methyl({[5-(pyridin-...)
Affinity DataKi:  180nMAssay Description:Effect on coumarin 7-hydroxylation by human Cytochrome P-450 2A6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM12343(CHEMBL369285 | US8609708, 9 | methyl({[5-(pyridin-...)
Affinity DataKi:  600nM ΔG°:  -36.9kJ/molepH: 7.5 T: 2°CAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM12343(CHEMBL369285 | US8609708, 9 | methyl({[5-(pyridin-...)
Affinity DataIC50:  1.10E+3nMAssay Description:The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay ...More data for this Ligand-Target Pair
In DepthDetails US Patent