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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphodiesterase Type 10 (PDE10A)' and Monomerid = 14746   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase Type 10 (PDE10A)


(Rattus norvegicus (rat))
BDBM14746
PNG
((R)-6,7-Dimethoxy-4-[3-(4-trifluoromethoxy-phenoxy...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc(OC(F)(F)F)cc3)c2cc1OC
Show InChI InChI=1S/C21H20F3N3O4/c1-28-18-9-16-17(10-19(18)29-2)25-12-26-20(16)27-8-7-15(11-27)30-13-3-5-14(6-4-13)31-21(22,23)24/h3-6,9-10,12,15H,7-8,11H2,1-2H3/t15-/m1/s1
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
185 -38.0n/an/an/an/an/a7.522



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair