Found 43 Enz. Inhib. hit(s) with Target = 'Mitogen-Activated Protein Kinase 1' and Monomerid = 15244
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University
Curated by ChEMBL
Boston University
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Inhibition of P38 mitogen activated protein kinase (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 220nMAssay Description:Inhibition of p38beta using KRELVEPLTPSGEAPNQALLR as substrate for 10 mins by lactate dehydrogenase-coupled spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University
Curated by ChEMBL
Boston University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant p38alpha by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Antagonist activity at p38 MAPK alpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of human p38-alpha kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:In vitro inhibitory activity determined against human mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University
Curated by ChEMBL
Boston University
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of MAPK p38 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University
Curated by ChEMBL
Boston University
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of LPS-induced p38-related Tumor necrosis factor alpha release by THP-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of p38alpha in human whole blood assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of p38alpha in human whole blood assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University
Curated by ChEMBL
Boston University
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of LPS-induced p38-related Tumor necrosis factor alpha release in human whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibitory activity against HIV-1 Y188L reverse transcriptase.More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of JNK3 by filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of Erk2 by filter binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human p38-alpha kinase phosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Graduate School Of Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Graduate School Of Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to p38gamma (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Graduate School Of Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Graduate School Of Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length p38-gammaMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK8 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.80nMAssay Description:Binding constant for full-length p38-alphaMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for full-length ERK2More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Graduate School Of Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Graduate School Of Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for p38-gamma kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for p38-delta kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for JNK3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 74nMAssay Description:Binding constant for p38-beta kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for TGFBR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK8 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.80nMAssay Description:Binding constant for p38-alpha kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ERK2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 160nMAssay Description:Average Binding Constant for p38-beta; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 3.20nMAssay Description:Average Binding Constant for p38-alpha; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for TGFBR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.80nMAssay Description:Binding affinity to p38alpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 74nMAssay Description:Binding constant for full-length p38-betaMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for JNK3 kinase domainMore data for this Ligand-Target Pair