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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Plasmin' and Monomerid = 16138   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM16138
PNG
(1-guanidino-7-sulfonamidoisoquinoline 12 | 3-({4-c...)
Show SMILES NC(N)=Nc1ncc(Cl)c2ccc(cc12)S(=O)(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H14ClN5O4S/c18-14-8-21-15(22-17(19)20)13-7-11(4-5-12(13)14)28(26,27)23-10-3-1-2-9(6-10)16(24)25/h1-8,23H,(H,24,25)(H4,19,20,21,22)
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Article
PubMed
59 -42.9n/an/an/an/an/a8.137



Pfizer Inc



Assay Description
Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...


J Med Chem 50: 2341-51 (2007)


Article DOI: 10.1021/jm061066t
BindingDB Entry DOI: 10.7270/Q27S7M18
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM16138
PNG
(1-guanidino-7-sulfonamidoisoquinoline 12 | 3-({4-c...)
Show SMILES NC(N)=Nc1ncc(Cl)c2ccc(cc12)S(=O)(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H14ClN5O4S/c18-14-8-21-15(22-17(19)20)13-7-11(4-5-12(13)14)28(26,27)23-10-3-1-2-9(6-10)16(24)25/h1-8,23H,(H,24,25)(H4,19,20,21,22)
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Article
PubMed
9.80E+3n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...


J Med Chem 50: 2341-51 (2007)


Article DOI: 10.1021/jm061066t
BindingDB Entry DOI: 10.7270/Q27S7M18
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM16138
PNG
(1-guanidino-7-sulfonamidoisoquinoline 12 | 3-({4-c...)
Show SMILES NC(N)=Nc1ncc(Cl)c2ccc(cc12)S(=O)(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H14ClN5O4S/c18-14-8-21-15(22-17(19)20)13-7-11(4-5-12(13)14)28(26,27)23-10-3-1-2-9(6-10)16(24)25/h1-8,23H,(H,24,25)(H4,19,20,21,22)
PDB
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Article
PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



Pfizer Inc



Assay Description
Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...


J Med Chem 50: 2341-51 (2007)


Article DOI: 10.1021/jm061066t
BindingDB Entry DOI: 10.7270/Q27S7M18
More data for this
Ligand-Target Pair