BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Histamine H4 Receptor' and Monomerid = 26394   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM26394
PNG
(2,4-diamino-5,6-disubstituted pyrimidine, 8 | 4-(p...)
Show SMILES Nc1nc-2c(Cc3ccccc-23)c(n1)N1CCNCC1
Show InChI InChI=1S/C15H17N5/c16-15-18-13-11-4-2-1-3-10(11)9-12(13)14(19-15)20-7-5-17-6-8-20/h1-4,17H,5-9H2,(H2,16,18,19)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
4.80 -47.5n/an/an/an/an/a7.425



Abbott Laboratories



Assay Description
Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...


J Med Chem 51: 6547-57 (2008)


Article DOI: 10.1021/jm800670r
BindingDB Entry DOI: 10.7270/Q2KH0KM5
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM26394
PNG
(2,4-diamino-5,6-disubstituted pyrimidine, 8 | 4-(p...)
Show SMILES Nc1nc-2c(Cc3ccccc-23)c(n1)N1CCNCC1
Show InChI InChI=1S/C15H17N5/c16-15-18-13-11-4-2-1-3-10(11)9-12(13)14(19-15)20-7-5-17-6-8-20/h1-4,17H,5-9H2,(H2,16,18,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
13 -45.0n/an/an/an/an/a7.425



Abbott Laboratories



Assay Description
Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...


J Med Chem 51: 6547-57 (2008)


Article DOI: 10.1021/jm800670r
BindingDB Entry DOI: 10.7270/Q2KH0KM5
More data for this
Ligand-Target Pair