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Found 1 hit Enz. Inhib. hit(s) with Target = '5-Lipoxygenase' and Monomerid = 31110   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM31110
PNG
(2-substituted indole-3-carboxylate, 27g)
Show SMILES COC(=O)c1c(NCC=C)[nH]c2ccccc12
Show InChI InChI=1S/C13H14N2O2/c1-3-8-14-12-11(13(16)17-2)9-6-4-5-7-10(9)15-12/h3-7,14-15H,1,8H2,2H3
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+4n/a>3.00E+4n/an/a7.437



Friedrich Alexander University Erlangen



Assay Description
For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...


J Med Chem 52: 3474-83 (2009)


Article DOI: 10.1021/jm900212y
BindingDB Entry DOI: 10.7270/Q2HM56S5
More data for this
Ligand-Target Pair