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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '5-Lipoxygenase' and Monomerid = 31133   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM31133
PNG
(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11l)
Show SMILES CCOC(=O)c1c([nH]c2c1cc(O)c1ccccc21)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H16ClNO3/c1-2-26-21(25)18-16-11-17(24)14-5-3-4-6-15(14)20(16)23-19(18)12-7-9-13(22)10-8-12/h3-11,23-24H,2H2,1H3
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MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 67n/a 320n/an/an/an/a



Friedrich Alexander University Erlangen



Assay Description
For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...


J Med Chem 52: 3474-83 (2009)


Article DOI: 10.1021/jm900212y
BindingDB Entry DOI: 10.7270/Q2HM56S5
More data for this
Ligand-Target Pair