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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Monomerid = 50004852   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50004852
PNG
(AMAA | Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...)
Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c1-2-3(4(7)6(10)11)5(9)8-12-2/h4H,7H2,1H3,(H,8,9)(H,10,11)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist activityof the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu2


J Med Chem 39: 3188-94 (1996)


Article DOI: 10.1021/jm9602569
BindingDB Entry DOI: 10.7270/Q2M909BH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50004852
PNG
(AMAA | Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-ac...)
Show SMILES Cc1o[nH]c(=O)c1C(N)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c1-2-3(4(7)6(10)11)5(9)8-12-2/h4H,7H2,1H3,(H,8,9)(H,10,11)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for agonistic activity against mGluR2 alpha metabotropic receptor subtype in rat cortical slice model


Bioorg Med Chem Lett 8: 1563-8 (1999)


Article DOI: 10.1016/s0960-894x(98)00264-9
BindingDB Entry DOI: 10.7270/Q27P8XJ2
More data for this
Ligand-Target Pair