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Found 3 hits Enz. Inhib. hit(s) with Target = 'Arachidonate 5-lipoxygenase' and Monomerid = 50012435   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50012435
PNG
(2-(4-Fluoro-phenyl)-5-phenyl-thiazol-4-ol | CHEMBL...)
Show SMILES Oc1nc(sc1-c1ccccc1)-c1ccc(F)cc1
Show InChI InChI=1S/C15H10FNOS/c16-12-8-6-11(7-9-12)15-17-14(18)13(19-15)10-4-2-1-3-5-10/h1-9,18H
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MMDB

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Article
PubMed
n/an/a 470n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of 5-lipoxygenase (5-lo) in human whole blood (HWBL)


J Med Chem 34: 2158-65 (1991)


Article DOI: 10.1021/jm00111a035
BindingDB Entry DOI: 10.7270/Q2NS0SWM
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50012435
PNG
(2-(4-Fluoro-phenyl)-5-phenyl-thiazol-4-ol | CHEMBL...)
Show SMILES Oc1nc(sc1-c1ccccc1)-c1ccc(F)cc1
Show InChI InChI=1S/C15H10FNOS/c16-12-8-6-11(7-9-12)15-17-14(18)13(19-15)10-4-2-1-3-5-10/h1-9,18H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Goethe-University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in rat RBL1 cells


Eur J Med Chem 89: 503-23 (2014)


Article DOI: 10.1016/j.ejmech.2014.10.054
BindingDB Entry DOI: 10.7270/Q2959K5T
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50012435
PNG
(2-(4-Fluoro-phenyl)-5-phenyl-thiazol-4-ol | CHEMBL...)
Show SMILES Oc1nc(sc1-c1ccccc1)-c1ccc(F)cc1
Show InChI InChI=1S/C15H10FNOS/c16-12-8-6-11(7-9-12)15-17-14(18)13(19-15)10-4-2-1-3-5-10/h1-9,18H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells


J Med Chem 34: 2158-65 (1991)


Article DOI: 10.1021/jm00111a035
BindingDB Entry DOI: 10.7270/Q2NS0SWM
More data for this
Ligand-Target Pair