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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Neprilysin' and Monomerid = 50034857   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neprilysin


(Homo sapiens (Human))
BDBM50034857
PNG
((2R,4S)-5-Biphenyl-4-yl-4-(5-carboxy-pentanoylamin...)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCCCC(O)=O)C(O)=O
Show InChI InChI=1S/C24H29NO5/c1-17(24(29)30)15-21(25-22(26)9-5-6-10-23(27)28)16-18-11-13-20(14-12-18)19-7-3-2-4-8-19/h2-4,7-8,11-14,17,21H,5-6,9-10,15-16H2,1H3,(H,25,26)(H,27,28)(H,29,30)/t17-,21+/m1/s1
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Similars

US Patent
n/an/a 324n/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...


US Patent US10123984 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9DVB
More data for this
Ligand-Target Pair