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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Neprilysin' and Monomerid = 50047222   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neprilysin


(Rattus norvegicus (Rat))
BDBM50047222
PNG
(2-[2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-...)
Show SMILES CCC(C)C(NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C(=O)NC(C(C)C)C(O)=O
Show InChI InChI=1S/C22H33N3O6/c1-5-14(4)19(21(28)23-18(13(2)3)22(29)30)24-20(27)16(12-17(26)25-31)11-15-9-7-6-8-10-15/h6-10,13-14,16,18-19,31H,5,11-12H2,1-4H3,(H,23,28)(H,24,27)(H,25,26)(H,29,30)/t14?,16-,18?,19?/m1/s1
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PC cid
PC sid
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Article
PubMed
31n/an/an/an/an/an/an/an/a



CCIPE-Faculté de Pharmacie

Curated by ChEMBL


Assay Description
Inhibitory activity against endopeptidase 24.15


J Med Chem 36: 1369-79 (1993)


Article DOI: 10.1021/jm00062a009
BindingDB Entry DOI: 10.7270/Q2736PZX
More data for this
Ligand-Target Pair
Neprilysin


(Rattus norvegicus (Rat))
BDBM50047222
PNG
(2-[2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-...)
Show SMILES CCC(C)C(NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C(=O)NC(C(C)C)C(O)=O
Show InChI InChI=1S/C22H33N3O6/c1-5-14(4)19(21(28)23-18(13(2)3)22(29)30)24-20(27)16(12-17(26)25-31)11-15-9-7-6-8-10-15/h6-10,13-14,16,18-19,31H,5,11-12H2,1-4H3,(H,23,28)(H,24,27)(H,25,26)(H,29,30)/t14?,16-,18?,19?/m1/s1
PDB
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KEGG

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B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
40n/an/an/an/an/an/an/an/a



CCIPE-Faculté de Pharmacie

Curated by ChEMBL


Assay Description
Inhibitory activity against endopeptidase 24.11


J Med Chem 36: 1369-79 (1993)


Article DOI: 10.1021/jm00062a009
BindingDB Entry DOI: 10.7270/Q2736PZX
More data for this
Ligand-Target Pair