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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = '5-Lipoxygenase' and Monomerid = 50053497   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50053497
PNG
(1-(6-Methoxy-pyridin-2-yl)-5-methyl-[1,2,4]triazin...)
Show SMILES COc1cccc(n1)N1CC(C)NC(=O)N1
Show InChI InChI=1S/C10H14N4O2/c1-7-6-14(13-10(15)11-7)8-4-3-5-9(12-8)16-2/h3-5,7H,6H2,1-2H3,(H2,11,13,15)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.50E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase catalysis in rat basophilic leukemia (RBL) cells by measuring 5-HETE product formation


J Med Chem 39: 3938-50 (1996)


Article DOI: 10.1021/jm960372b
BindingDB Entry DOI: 10.7270/Q2GQ6WWW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50053497
PNG
(1-(6-Methoxy-pyridin-2-yl)-5-methyl-[1,2,4]triazin...)
Show SMILES COc1cccc(n1)N1CC(C)NC(=O)N1
Show InChI InChI=1S/C10H14N4O2/c1-7-6-14(13-10(15)11-7)8-4-3-5-9(12-8)16-2/h3-5,7H,6H2,1-2H3,(H2,11,13,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro 5-lipoxygenase inhibitory activity against calcium ionophore (A23187) induced LTB4 formation in human polymorphonuclear leukocytes.


J Med Chem 39: 3938-50 (1996)


Article DOI: 10.1021/jm960372b
BindingDB Entry DOI: 10.7270/Q2GQ6WWW
More data for this
Ligand-Target Pair