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Found 2 hits Enz. Inhib. hit(s) with Target = '5-Lipoxygenase' and Monomerid = 50058634   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50058634
PNG
(CHEMBL291840 | N-[1-(2-furyl)ethyl]-N-hydroxyurea)
Show SMILES CC(N(O)C(N)=O)c1ccco1
Show InChI InChI=1S/C7H10N2O3/c1-5(9(11)7(8)10)6-3-2-4-12-6/h2-5,11H,1H3,(H2,8,10)
PDB
MMDB

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PC sid
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Article
PubMed
n/an/a 1.95E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).


J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50058634
PNG
(CHEMBL291840 | N-[1-(2-furyl)ethyl]-N-hydroxyurea)
Show SMILES CC(N(O)C(N)=O)c1ccco1
Show InChI InChI=1S/C7H10N2O3/c1-5(9(11)7(8)10)6-3-2-4-12-6/h2-5,11H,1H3,(H2,8,10)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.40E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production


J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair