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Found 1 hit Enz. Inhib. hit(s) with Target = '5-Lipoxygenase' and Monomerid = 50059714   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50059714
PNG
(4-Furan-3-yl-7-[5-(4-hydroxy-tetrahydro-pyran-4-yl...)
Show SMILES OC1(CCOCC1)c1cncc(COc2ccc3c(cc(cc3c2)C#N)-c2ccoc2)c1
Show InChI InChI=1S/C26H22N2O4/c27-13-18-9-21-12-23(1-2-24(21)25(11-18)20-3-6-31-17-20)32-16-19-10-22(15-28-14-19)26(29)4-7-30-8-5-26/h1-3,6,9-12,14-15,17,29H,4-5,7-8,16H2
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of oxidation of arachidonic acid by human 5-Lipoxygenase using spectrophotometric assay


J Med Chem 40: 2866-75 (1997)


Article DOI: 10.1021/jm970046b
BindingDB Entry DOI: 10.7270/Q2QN67G4
More data for this
Ligand-Target Pair