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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '5-Lipoxygenase' and Monomerid = 50059717   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50059717
PNG
(4-(furan-3-yl)-7-((6-(4-hydroxytetrahydro-2H-pyran...)
Show SMILES OC1(CCOCC1)c1cccc(COc2ccc3c(cc(cc3c2)C#N)-c2ccoc2)n1
Show InChI InChI=1S/C26H22N2O4/c27-15-18-12-20-14-22(4-5-23(20)24(13-18)19-6-9-31-16-19)32-17-21-2-1-3-25(28-21)26(29)7-10-30-11-8-26/h1-6,9,12-14,16,29H,7-8,10-11,17H2
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MMDB

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Similars

Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Compound was evaluated for the potency to inhibit oxidation of arachidonic acid by human recombinant 5-Lipoxygenase using a spectrophotometric assay


J Med Chem 40: 2866-75 (1997)


Article DOI: 10.1021/jm970046b
BindingDB Entry DOI: 10.7270/Q2QN67G4
More data for this
Ligand-Target Pair