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Found 1 hit Enz. Inhib. hit(s) with Target = 'Telomerase reverse transcriptase' and Monomerid = 50068325   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50068325
PNG
(CHEMBL146602 | N-[9,10-Dioxo-7-(3-(N-methylpyrroli...)
Show SMILES C[N+]1(CCC(=O)Nc2ccc3C(=O)c4ccc(NC(=O)CC[N+]5(C)CCCC5)cc4C(=O)c3c2)CCCC1
Show InChI InChI=1S/C30H36N4O4/c1-33(13-3-4-14-33)17-11-27(35)31-21-7-9-23-25(19-21)30(38)26-20-22(8-10-24(26)29(23)37)32-28(36)12-18-34(2)15-5-6-16-34/h7-10,19-20H,3-6,11-18H2,1-2H3/p+2
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Similars

Article
PubMed
n/an/a 1.60E+4n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibitory activity of telomerase was measured using the TRAP assay.


J Med Chem 41: 4873-84 (1998)


Article DOI: 10.1021/jm981067o
BindingDB Entry DOI: 10.7270/Q2WW7GSD
More data for this
Ligand-Target Pair