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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Matrix metalloproteinase 12' and Monomerid = 50068849   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix metalloproteinase 12


(Mus musculus)
BDBM50068849
PNG
((R)-2-[(4-Methoxy-benzenesulfonyl)-pyridin-2-ylmet...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccn1)[C@H](CC(C)C)C(=O)NO
Show InChI InChI=1S/C19H25N3O5S/c1-14(2)12-18(19(23)21-24)22(13-15-6-4-5-11-20-15)28(25,26)17-9-7-16(27-3)8-10-17/h4-11,14,18,24H,12-13H2,1-3H3,(H,21,23)/t18-/m1/s1
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Article
PubMed
n/an/a 6.90n/an/an/an/an/an/a



Novartis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against mouse macrophage metalloelastase (MME) using [3H]elastin as a substrate


Bioorg Med Chem Lett 8: 897-902 (1999)


Article DOI: 10.1016/s0960-894x(98)00142-5
BindingDB Entry DOI: 10.7270/Q2NP24ZC
More data for this
Ligand-Target Pair