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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 1' and Monomerid = 50071161   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50071161
PNG
((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1
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PC cid
PC sid
UniChem

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Article
PubMed
>1.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human metabotropic glutamate receptor 1


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50071161
PNG
((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 4 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50071161
PNG
((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...)
Show SMILES N[C@@]1(C[C@@H](N(Cc2ccccc2)C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H16N2O4/c14-13(12(18)19)6-10(11(16)17)15(8-13)7-9-4-2-1-3-5-9/h1-5,10H,6-8,14H2,(H,16,17)(H,18,19)/t10-,13-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 1 expressed in RGT cells.


Bioorg Med Chem Lett 8: 1985-90 (1999)


Article DOI: 10.1016/s0960-894x(98)00352-7
BindingDB Entry DOI: 10.7270/Q2K35V5D
More data for this
Ligand-Target Pair