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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M1' and Monomerid = 50071181   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50071181
PNG
(8,9-Dimethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)c(OC)cc45)Cc3c12
Show InChI InChI=1/C24H26N2O5/c1-5-30-24(27)21-13(2)25-17-6-7-18-16(22(17)21)12-26-9-8-14-10-19(28-3)20(29-4)11-15(14)23(26)31-18/h6-7,10-11,23,25H,5,8-9,12H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.29E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]NMS binding using membranes in transfected chinese hamster ...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50071181
PNG
(8,9-Dimethoxy-2-methyl-11,12-dihydro-3H,6aH,13H-6-...)
Show SMILES CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)c(OC)cc45)Cc3c12
Show InChI InChI=1/C24H26N2O5/c1-5-30-24(27)21-13(2)25-17-6-7-18-16(22(17)21)12-26-9-8-14-10-19(28-3)20(29-4)11-15(14)23(26)31-18/h6-7,10-11,23,25H,5,8-9,12H2,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.66E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...


Bioorg Med Chem Lett 8: 1991-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00351-5
BindingDB Entry DOI: 10.7270/Q2FB53F2
More data for this
Ligand-Target Pair