BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Telomerase reverse transcriptase' and Monomerid = 50079123   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50079123
PNG
(3-(4-Hydroxy-piperidin-1-yl)-N-{7-[3-(4-hydroxy-pi...)
Show SMILES OC1CCN(CCC(=O)Nc2ccc3-c4ccc(NC(=O)CCN5CCC(O)CC5)cc4C(=O)c3c2)CC1
Show InChI InChI=1S/C29H36N4O5/c34-21-5-11-32(12-6-21)15-9-27(36)30-19-1-3-23-24-4-2-20(18-26(24)29(38)25(23)17-19)31-28(37)10-16-33-13-7-22(35)8-14-33/h1-4,17-18,21-22,34-35H,5-16H2,(H,30,36)(H,31,37)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.85E+4n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibitory activity against telomerase


J Med Chem 42: 2679-84 (1999)


Article DOI: 10.1021/jm990084q
BindingDB Entry DOI: 10.7270/Q2DF6RX9
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50079123
PNG
(3-(4-Hydroxy-piperidin-1-yl)-N-{7-[3-(4-hydroxy-pi...)
Show SMILES OC1CCN(CCC(=O)Nc2ccc3-c4ccc(NC(=O)CCN5CCC(O)CC5)cc4C(=O)c3c2)CC1
Show InChI InChI=1S/C29H36N4O5/c34-21-5-11-32(12-6-21)15-9-27(36)30-19-1-3-23-24-4-2-20(18-26(24)29(38)25(23)17-19)31-28(37)10-16-33-13-7-22(35)8-14-33/h1-4,17-18,21-22,34-35H,5-16H2,(H,30,36)(H,31,37)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

n/an/a 1.86E+10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of telomerase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair