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Found 2 hits Enz. Inhib. hit(s) with Target = 'Telomerase reverse transcriptase' and Monomerid = 50079146   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50079146
PNG
(3-Dimethylamino-N-[7-(3-dimethylamino-propionylami...)
Show SMILES CN(C)CCC(=O)Nc1ccc2-c3ccc(NC(=O)CCN(C)C)cc3C(=O)c2c1
Show InChI InChI=1S/C23H28N4O3/c1-26(2)11-9-21(28)24-15-5-7-17-18-8-6-16(25-22(29)10-12-27(3)4)14-20(18)23(30)19(17)13-15/h5-8,13-14H,9-12H2,1-4H3,(H,24,28)(H,25,29)
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.62E+4n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibitory activity against telomerase


J Med Chem 42: 2679-84 (1999)


Article DOI: 10.1021/jm990084q
BindingDB Entry DOI: 10.7270/Q2DF6RX9
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50079146
PNG
(3-Dimethylamino-N-[7-(3-dimethylamino-propionylami...)
Show SMILES CN(C)CCC(=O)Nc1ccc2-c3ccc(NC(=O)CCN(C)C)cc3C(=O)c2c1
Show InChI InChI=1S/C23H28N4O3/c1-26(2)11-9-21(28)24-15-5-7-17-18-8-6-16(25-22(29)10-12-27(3)4)14-20(18)23(30)19(17)13-15/h5-8,13-14H,9-12H2,1-4H3,(H,24,28)(H,25,29)
PDB

NCI pathway
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KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

n/an/a 1.62E+10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of telomerase (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair