BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Telomerase reverse transcriptase' and Monomerid = 50080852   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50080852
PNG
(3,6-Bis[3-(heptamethyleneimino)piperizinopropionam...)
Show SMILES O=C(CCN1CCCCCCC1)Nc1ccc2cc3ccc(NC(=O)CCN4CCCCCCC4)cc3nc2c1
Show InChI InChI=1S/C33H45N5O2/c39-32(15-21-37-17-7-3-1-4-8-18-37)34-28-13-11-26-23-27-12-14-29(25-31(27)36-30(26)24-28)35-33(40)16-22-38-19-9-5-2-6-10-20-38/h11-14,23-25H,1-10,15-22H2,(H,34,39)(H,35,40)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Ability to inhibit human telomerase in a modified cell-free TRAP assay using extracts from A2780 cell line


Bioorg Med Chem Lett 9: 2463-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00394-7
BindingDB Entry DOI: 10.7270/Q2H41QN7
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50080852
PNG
(3,6-Bis[3-(heptamethyleneimino)piperizinopropionam...)
Show SMILES O=C(CCN1CCCCCCC1)Nc1ccc2cc3ccc(NC(=O)CCN4CCCCCCC4)cc3nc2c1
Show InChI InChI=1S/C33H45N5O2/c39-32(15-21-37-17-7-3-1-4-8-18-37)34-28-13-11-26-23-27-12-14-29(25-31(27)36-30(26)24-28)35-33(40)16-22-38-19-9-5-2-6-10-20-38/h11-14,23-25H,1-10,15-22H2,(H,34,39)(H,35,40)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibitory activity against Telomerase evaluated by TRAP Assay studies.


J Med Chem 42: 4538-46 (1999)


Article DOI: 10.1021/jm990287e
BindingDB Entry DOI: 10.7270/Q2J103VC
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50080852
PNG
(3,6-Bis[3-(heptamethyleneimino)piperizinopropionam...)
Show SMILES O=C(CCN1CCCCCCC1)Nc1ccc2cc3ccc(NC(=O)CCN4CCCCCCC4)cc3nc2c1
Show InChI InChI=1S/C33H45N5O2/c39-32(15-21-37-17-7-3-1-4-8-18-37)34-28-13-11-26-23-27-12-14-29(25-31(27)36-30(26)24-28)35-33(40)16-22-38-19-9-5-2-6-10-20-38/h11-14,23-25H,1-10,15-22H2,(H,34,39)(H,35,40)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Eur J Med Chem 44: 4826-40 (2009)


Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM
More data for this
Ligand-Target Pair