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Found 5 Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Monomerid = 50086551
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataKi:  43nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataIC50:  73nMAssay Description:Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataIC50:  113nMAssay Description:Cross-reactivity as binding to human glucocorticoid receptor (hGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataIC50: >1.00E+3nMAssay Description:Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed