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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Monomerid = 50089901   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 2 using established second messenger assay systems.


J Med Chem 45: 988-91 (2002)


Article DOI: 10.1021/jm010443t
BindingDB Entry DOI: 10.7270/Q2M32V27
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Antagonist potency against cloned Metabotropic glutamate receptor 2


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+6n/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2


J Med Chem 45: 4240-5 (2002)


Article DOI: 10.1021/jm020122x
BindingDB Entry DOI: 10.7270/Q28G8K2W
More data for this
Ligand-Target Pair