BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 8 hits Enz. Inhib. hit(s) with Target = 'Excitatory amino acid transporter 3' and Monomerid = 50093753   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.70E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-Asp uptake at human EAAT3 expressed in HEK293 cells measured after 3 mins by TopCount method


J Med Chem 59: 8771-8786 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01066
BindingDB Entry DOI: 10.7270/Q2Z03B4C
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.72E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-Asp uptake at human EAAT3 expressed in HEK293 cells measured after 3 mins by TopCount method


J Med Chem 59: 8771-8786 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01066
BindingDB Entry DOI: 10.7270/Q2Z03B4C
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of human EAAC1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation counting


J Med Chem 53: 7236-50 (2010)


Article DOI: 10.1021/jm100959g
BindingDB Entry DOI: 10.7270/Q27081NR
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



The University of Montana

Curated by ChEMBL


Assay Description
Inhibition of [14C]glutamate uptake at human EAAT3 expressed in african green monkey COS1 cells


Bioorg Med Chem 16: 7740-8 (2008)


Article DOI: 10.1016/j.bmc.2008.07.001
BindingDB Entry DOI: 10.7270/Q2TM79XR
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.34E+5n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50093753
PNG
((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...)
Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.61E+5n/an/an/an/an/an/a



Institute for Bioorganic Research

Curated by ChEMBL


Assay Description
Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 10: 2407-10 (2001)

Checked by Author
Article DOI: 10.1016/s0960-894x(00)00487-x
BindingDB Entry DOI: 10.7270/Q2CR5TVN
More data for this
Ligand-Target Pair