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Found 2 hits Enz. Inhib. hit(s) with Target = 'Telomerase reverse transcriptase' and Monomerid = 50108802   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50108802
PNG
(3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]a...)
Show SMILES Cc1cc2n(C)c3ccc(F)cc3c3[n+](C)c4ccc(F)cc4c(c1)c23
Show InChI InChI=1S/C22H17F2N2/c1-12-8-16-15-10-13(23)4-6-18(15)26(3)22-17-11-14(24)5-7-19(17)25(2)20(9-12)21(16)22/h4-11H,1-3H3/q+1
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
PDB
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Similars

Article
PubMed
n/an/a 330n/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of telomerase activity using TRAP assay


J Med Chem 45: 590-7 (2002)


Article DOI: 10.1021/jm011015q
BindingDB Entry DOI: 10.7270/Q2BR8RGQ
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50108802
PNG
(3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]a...)
Show SMILES Cc1cc2n(C)c3ccc(F)cc3c3[n+](C)c4ccc(F)cc4c(c1)c23
Show InChI InChI=1S/C22H17F2N2/c1-12-8-16-15-10-13(23)4-6-18(15)26(3)22-17-11-14(24)5-7-19(17)25(2)20(9-12)21(16)22/h4-11H,1-3H3/q+1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

n/an/a 3.31E+8n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Homo sapiens (human) telomerase assessed as formation of G-tetraplexes by gel mobility shift assay


Citation and Details
More data for this
Ligand-Target Pair