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Found 1 hit Enz. Inhib. hit(s) with Target = 'Histamine N-methyltransferase' and Monomerid = 50110283   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine N-methyltransferase


(Rattus norvegicus)
BDBM50110283
PNG
((7-Chloro-quinolin-4-yl)-(4-piperidin-1-yl-butyl)-...)
Show SMILES Clc1ccc2c(NCCCCN3CCCCC3)ccnc2c1
Show InChI InChI=1S/C18H24ClN3/c19-15-6-7-16-17(8-10-21-18(16)14-15)20-9-2-5-13-22-11-3-1-4-12-22/h6-8,10,14H,1-5,9,11-13H2,(H,20,21)
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine


J Med Chem 45: 1128-41 (2002)


Article DOI: 10.1021/jm0110845
BindingDB Entry DOI: 10.7270/Q2H70F4V
More data for this
Ligand-Target Pair