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Found 1 hit Enz. Inhib. hit(s) with Target = 'Histamine N-methyltransferase' and Monomerid = 50110308   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine N-methyltransferase


(Rattus norvegicus)
BDBM50110308
PNG
((7-Chloro-quinolin-4-yl)-{2-[4-(3-piperidin-1-yl-p...)
Show SMILES Clc1ccc2c(NCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1
Show InChI InChI=1S/C25H30ClN3O/c26-21-7-10-23-24(12-14-28-25(23)19-21)27-13-11-20-5-8-22(9-6-20)30-18-4-17-29-15-2-1-3-16-29/h5-10,12,14,19H,1-4,11,13,15-18H2,(H,27,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 420n/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine


J Med Chem 45: 1128-41 (2002)


Article DOI: 10.1021/jm0110845
BindingDB Entry DOI: 10.7270/Q2H70F4V
More data for this
Ligand-Target Pair