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Found 1 hit Enz. Inhib. hit(s) with Target = '5-Lipoxygenase' and Monomerid = 50138991   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50138991
PNG
(1-{4-[3-Fluoro-5-(4-methanesulfonyl-tetrahydro-pyr...)
Show SMILES Cc1nccn1-c1ccc(COc2cc(F)cc(c2)C2(CCOCC2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C23H25FN2O4S/c1-17-25-9-10-26(17)21-5-3-18(4-6-21)16-30-22-14-19(13-20(24)15-22)23(31(2,27)28)7-11-29-12-8-23/h3-6,9-10,13-15H,7-8,11-12,16H2,1-2H3
PDB
MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of 5-Lipoxygenase (5-LO) of human whole blood (HWB)


J Med Chem 47: 720-5 (2004)


Article DOI: 10.1021/jm0303554
BindingDB Entry DOI: 10.7270/Q2P26XKK
More data for this
Ligand-Target Pair