BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Plasmin' and Monomerid = 50147402   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50147402
PNG
(CHEMBL323241 | N-(7-Phenyl-isoquinolin-1-yl)-guani...)
Show SMILES NC(N)=Nc1nccc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C16H14N4/c17-16(18)20-15-14-10-13(11-4-2-1-3-5-11)7-6-12(14)8-9-19-15/h1-10H,(H4,17,18,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
400n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against human urokinase-type plasminogen activator was evaluated using S-2444 as substrate


Bioorg Med Chem Lett 14: 3227-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.094
BindingDB Entry DOI: 10.7270/Q2125S3C
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50147402
PNG
(CHEMBL323241 | N-(7-Phenyl-isoquinolin-1-yl)-guani...)
Show SMILES NC(N)=Nc1nccc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C16H14N4/c17-16(18)20-15-14-10-13(11-4-2-1-3-5-11)7-6-12(14)8-9-19-15/h1-10H,(H4,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.75E+4n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human plasmin activity with chromozym-PL as substrate


Bioorg Med Chem Lett 14: 3227-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.094
BindingDB Entry DOI: 10.7270/Q2125S3C
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50147402
PNG
(CHEMBL323241 | N-(7-Phenyl-isoquinolin-1-yl)-guani...)
Show SMILES NC(N)=Nc1nccc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C16H14N4/c17-16(18)20-15-14-10-13(11-4-2-1-3-5-11)7-6-12(14)8-9-19-15/h1-10H,(H4,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.24E+5n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against human tissue type plasminogen activator using S-2444


Bioorg Med Chem Lett 14: 3227-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.094
BindingDB Entry DOI: 10.7270/Q2125S3C
More data for this
Ligand-Target Pair