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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Plasmin' and Monomerid = 50147412   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50147412
PNG
(CHEMBL321822 | N-Isoquinolin-1-yl-guanidine)
Show SMILES NC(N)=Nc1nccc2ccccc12
Show InChI InChI=1S/C10H10N4/c11-10(12)14-9-8-4-2-1-3-7(8)5-6-13-9/h1-6H,(H4,11,12,13,14)
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Article
PubMed
1.92E+3n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against human urokinase-type plasminogen activator was evaluated using S-2444 as substrate


Bioorg Med Chem Lett 14: 3227-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.094
BindingDB Entry DOI: 10.7270/Q2125S3C
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50147412
PNG
(CHEMBL321822 | N-Isoquinolin-1-yl-guanidine)
Show SMILES NC(N)=Nc1nccc2ccccc12
Show InChI InChI=1S/C10H10N4/c11-10(12)14-9-8-4-2-1-3-7(8)5-6-13-9/h1-6H,(H4,11,12,13,14)
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Article
PubMed
6.80E+4n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against human plasmin was evaluated using chromozym-PL as substrate at 1 mM


Bioorg Med Chem Lett 14: 3227-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.094
BindingDB Entry DOI: 10.7270/Q2125S3C
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50147412
PNG
(CHEMBL321822 | N-Isoquinolin-1-yl-guanidine)
Show SMILES NC(N)=Nc1nccc2ccccc12
Show InChI InChI=1S/C10H10N4/c11-10(12)14-9-8-4-2-1-3-7(8)5-6-13-9/h1-6H,(H4,11,12,13,14)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.26E+5n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against human tissue type plasminogen activator using S-2444


Bioorg Med Chem Lett 14: 3227-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.094
BindingDB Entry DOI: 10.7270/Q2125S3C
More data for this
Ligand-Target Pair