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Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Monomerid = 50154972   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50154972
PNG
(CHEMBL366333 | [3-Fluoro-5-(5-pyridin-2-yl-tetrazo...)
Show SMILES Fc1cc(Nc2cccnc2)cc(c1)-n1nnc(n1)-c1ccccn1
Show InChI InChI=1S/C17H12FN7/c18-12-8-14(21-13-4-3-6-19-11-13)10-15(9-12)25-23-17(22-24-25)16-5-1-2-7-20-16/h1-11,21H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 124n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5473-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.012
BindingDB Entry DOI: 10.7270/Q2F47NMM
More data for this
Ligand-Target Pair