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Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Monomerid = 50154976   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50154976
PNG
(2-{2-[3-(pyridin-2-yloxy)phenyl]-2H-tetrazol-5-yl}...)
Show SMILES O(c1cccc(c1)-n1nnc(n1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C17H12N6O/c1-3-10-18-15(8-1)17-20-22-23(21-17)13-6-5-7-14(12-13)24-16-9-2-4-11-19-16/h1-12H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.86E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5473-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.012
BindingDB Entry DOI: 10.7270/Q2F47NMM
More data for this
Ligand-Target Pair