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Found 1 hit Enz. Inhib. hit(s) with Target = '5-Lipoxygenase' and Monomerid = 50155335   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50155335
PNG
(1-{4-[4-(3-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]...)
Show SMILES NC(=O)N(O)CCC#Cc1ccc(OCCCN2CCN(CC2)[C@H](c2ccccc2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C31H35ClN4O3/c32-28-14-12-27(13-15-28)30(26-8-2-1-3-9-26)35-22-20-34(21-23-35)18-6-24-39-29-16-10-25(11-17-29)7-4-5-19-36(38)31(33)37/h1-3,8-17,30,38H,5-6,18-24H2,(H2,33,37)/t30-/m1/s1
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Article
PubMed
n/an/a 96n/an/an/an/an/an/a



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Curated by ChEMBL


Assay Description
Inhibition of 5-lipooxygenase activity in human whole blood assay


Bioorg Med Chem Lett 14: 5591-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.060
BindingDB Entry DOI: 10.7270/Q28C9VRH
More data for this
Ligand-Target Pair