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Found 4 Enz. Inhib. hit(s) with Target = 'Heat shock protein HSP 90-alpha' and Monomerid = 50165315
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165315(9-Pent-4-ynyl-8-(2,4,5-trichloro-phenylsulfanyl)-9...)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibition of Hsp90 protein as degradation of HER2 kinase in SKBr3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50165315(9-Pent-4-ynyl-8-(2,4,5-trichloro-phenylsulfanyl)-9...)
Affinity DataIC50: >2.00E+5nMAssay Description:Displacement of Cy3B-GM from recombinant Hsp90alpha (unknown origin) after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50165315(9-Pent-4-ynyl-8-(2,4,5-trichloro-phenylsulfanyl)-9...)
Affinity DataEC50:  8.50E+3nMAssay Description:The biochemical assay tests competitive binding of compounds to recombinant Hsp90α protein and also Hsp90 found in cell specific complexes, and ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHeat shock protein HSP 90-alpha(Mus musculus)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165315(9-Pent-4-ynyl-8-(2,4,5-trichloro-phenylsulfanyl)-9...)
Affinity DataEC50:  8.50E+3nMAssay Description:Displacement of 5 nM GM-BODIPY from mouse heat shock protein HSP90-alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed