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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Glycine transporter 1' and Monomerid = 50178424   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine transporter 1


(Homo sapiens (Human))
BDBM50178424
PNG
((2S)-2-((2-(4,5-dichloro-6-methoxy-1,3-dioxo-2-phe...)
Show SMILES COc1cc2C(=O)C(CCN(C)[C@@H](CO)C(O)=O)(C(=O)c2c(Cl)c1Cl)c1ccccc1
Show InChI InChI=1S/C22H21Cl2NO6/c1-25(14(11-26)21(29)30)9-8-22(12-6-4-3-5-7-12)19(27)13-10-15(31-2)17(23)18(24)16(13)20(22)28/h3-7,10,14,26H,8-9,11H2,1-2H3,(H,29,30)/t14-,22?/m0/s1
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Similars

Article
PubMed
n/an/a 2.90n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1


Bioorg Med Chem Lett 16: 1388-91 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.041
BindingDB Entry DOI: 10.7270/Q29C6X13
More data for this
Ligand-Target Pair