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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Monomerid = 50179657   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50179657
PNG
((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(6-...)
Show SMILES Cc1cccnc1NC(=O)Nc1nc(O)cn1C
Show InChI InChI=1S/C11H13N5O2/c1-7-4-3-5-12-9(7)14-11(18)15-10-13-8(17)6-16(10)2/h3-6,17H,1-2H3,(H2,12,13,14,15,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 320n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from mGlu5 receptor


Bioorg Med Chem Lett 17: 1307-11 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.033
BindingDB Entry DOI: 10.7270/Q2V987R8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50179657
PNG
((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(6-...)
Show SMILES Cc1cccnc1NC(=O)Nc1nc(O)cn1C
Show InChI InChI=1S/C11H13N5O2/c1-7-4-3-5-12-9(7)14-11(18)15-10-13-8(17)6-16(10)2/h3-6,17H,1-2H3,(H2,12,13,14,15,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 681n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at mGluR5 by FLIPR


Bioorg Med Chem Lett 17: 1307-11 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.033
BindingDB Entry DOI: 10.7270/Q2V987R8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50179657
PNG
((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(6-...)
Show SMILES Cc1cccnc1NC(=O)Nc1nc(O)cn1C
Show InChI InChI=1S/C11H13N5O2/c1-7-4-3-5-12-9(7)14-11(18)15-10-13-8(17)6-16(10)2/h3-6,17H,1-2H3,(H2,12,13,14,15,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.90E+3n/an/an/an/an/an/a



AstraZeneca R&D

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR


Bioorg Med Chem Lett 16: 1142-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.092
BindingDB Entry DOI: 10.7270/Q2697348
More data for this
Ligand-Target Pair