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Found 2 hits Enz. Inhib. hit(s) with Target = 'Cyclooxygenase-1' and Monomerid = 50190335   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclooxygenase-1 (COX-1)


(Homo sapiens (Human))
BDBM50190335
PNG
(4-((3-chloro-4-hydroxyphenyl)diazenyl)benzenesulfo...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N=Nc1ccc(O)c(Cl)c1
Show InChI InChI=1S/C12H10ClN3O3S/c13-11-7-9(3-6-12(11)17)16-15-8-1-4-10(5-2-8)20(14,18)19/h1-7,17H,(H2,14,18,19)
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.33E+4n/an/an/an/an/an/a



National Research Institute of Chinese Medicine

Curated by ChEMBL


Assay Description
Inhibition of COX1 assessed as TBX2 production in human whole blood


Bioorg Med Chem Lett 16: 4440-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.036
BindingDB Entry DOI: 10.7270/Q2ZS2W33
More data for this
Ligand-Target Pair
Cyclooxygenase-1 (COX-1)


(Homo sapiens (Human))
BDBM50190335
PNG
(4-((3-chloro-4-hydroxyphenyl)diazenyl)benzenesulfo...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N=Nc1ccc(O)c(Cl)c1
Show InChI InChI=1S/C12H10ClN3O3S/c13-11-7-9(3-6-12(11)17)16-15-8-1-4-10(5-2-8)20(14,18)19/h1-7,17H,(H2,14,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.05E+4n/an/an/an/an/an/a



National Research Institute of Chinese Medicine

Curated by ChEMBL


Assay Description
Inhibition of ovine COX1


Bioorg Med Chem Lett 16: 4440-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.036
BindingDB Entry DOI: 10.7270/Q2ZS2W33
More data for this
Ligand-Target Pair