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Found 4 Enz. Inhib. hit(s) with Target = 'Chymase' and Monomerid = 50210730
TargetChymase(Homo sapiens (Human))
Daiichi Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50210730(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Daiichi Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50210730(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Daiichi Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50210730(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Daiichi Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50210730(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Affinity DataKon:  1.25E-7M-1s-1Assay Description:Binding affinity to recombinant human chymase assessed as dissociation constant at 6 to 1000 nM by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed