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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Monomerid = 50214074   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50214074
PNG
(3-(5-(4-chlorophenyl)-6-methyl-4-oxo-4,5-dihydropy...)
Show SMILES Cc1nc2n(ncc2c(=O)n1-c1ccc(Cl)cc1)-c1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C18H14ClN5O3S/c1-11-22-17-16(18(25)23(11)13-7-5-12(19)6-8-13)10-21-24(17)14-3-2-4-15(9-14)28(20,26)27/h2-10H,1H3,(H2,20,26,27)
PDB
MMDB

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Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR5 receptor expressed in 132N1 cells assessed as inhibition of glutamate-induced calcium flux by FLIPR assay


Bioorg Med Chem Lett 17: 4303-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.028
BindingDB Entry DOI: 10.7270/Q2445M5T
More data for this
Ligand-Target Pair