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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 1' and Monomerid = 50214077   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50214077
PNG
(5-cycloheptyl-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]...)
Show SMILES Cc1nc2n(ncc2c(=O)n1C1CCCCCC1)-c1ccccc1
Show InChI InChI=1S/C19H22N4O/c1-14-21-18-17(13-20-23(18)16-11-7-4-8-12-16)19(24)22(14)15-9-5-2-3-6-10-15/h4,7-8,11-13,15H,2-3,5-6,9-10H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 760n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR1 receptor expressed in 132N1 cells assessed as inhibition of glutamate-induced calcium flux by FLIPR assay


Bioorg Med Chem Lett 17: 4303-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.028
BindingDB Entry DOI: 10.7270/Q2445M5T
More data for this
Ligand-Target Pair