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Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 1' and Monomerid = 50214086   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50214086
PNG
(5-(3-chlorophenyl)-6-methyl-1-phenyl-1H-pyrazolo[3...)
Show SMILES Cc1nc2n(ncc2c(=O)n1-c1cccc(Cl)c1)-c1ccccc1
Show InChI InChI=1S/C18H13ClN4O/c1-12-21-17-16(11-20-23(17)14-7-3-2-4-8-14)18(24)22(12)15-9-5-6-13(19)10-15/h2-11H,1H3
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR1 receptor expressed in 132N1 cells assessed as inhibition of glutamate-induced calcium flux by FLIPR assay


Bioorg Med Chem Lett 17: 4303-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.028
BindingDB Entry DOI: 10.7270/Q2445M5T
More data for this
Ligand-Target Pair