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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Monomerid = 50235559   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50235559
PNG
(CHEMBL399674 | N-(3-fluoro-4-(5-methyl-6-(2-(4-met...)
Show SMILES CN1CCN(CCOc2cn3ncnc(Oc4ccc(NC(=O)c5cccs5)cc4F)c3c2C)CC1
Show InChI InChI=1S/C25H27FN6O3S/c1-17-21(34-12-11-31-9-7-30(2)8-10-31)15-32-23(17)25(27-16-28-32)35-20-6-5-18(14-19(20)26)29-24(33)22-4-3-13-36-22/h3-6,13-16H,7-12H2,1-2H3,(H,29,33)
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Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50235559
PNG
(CHEMBL399674 | N-(3-fluoro-4-(5-methyl-6-(2-(4-met...)
Show SMILES CN1CCN(CCOc2cn3ncnc(Oc4ccc(NC(=O)c5cccs5)cc4F)c3c2C)CC1
Show InChI InChI=1S/C25H27FN6O3S/c1-17-21(34-12-11-31-9-7-30(2)8-10-31)15-32-23(17)25(27-16-28-32)35-20-6-5-18(14-19(20)26)29-24(33)22-4-3-13-36-22/h3-6,13-16H,7-12H2,1-2H3,(H,29,33)
PDB
MMDB

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KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system


Bioorg Med Chem Lett 18: 1945-51 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV
More data for this
Ligand-Target Pair