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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Monomerid = 50235575   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50235575
PNG
(CHEMBL253222 | N-(4-(6-(3-(dimethylamino)propoxy)-...)
Show SMILES CN(C)CCCOc1cn2ncnc(Oc3ccc(NC(=O)c4cccnc4)cc3F)c2c1C
Show InChI InChI=1S/C24H25FN6O3/c1-16-21(33-11-5-10-30(2)3)14-31-22(16)24(27-15-28-31)34-20-8-7-18(12-19(20)25)29-23(32)17-6-4-9-26-13-17/h4,6-9,12-15H,5,10-11H2,1-3H3,(H,29,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50235575
PNG
(CHEMBL253222 | N-(4-(6-(3-(dimethylamino)propoxy)-...)
Show SMILES CN(C)CCCOc1cn2ncnc(Oc3ccc(NC(=O)c4cccnc4)cc3F)c2c1C
Show InChI InChI=1S/C24H25FN6O3/c1-16-21(33-11-5-10-30(2)3)14-31-22(16)24(27-15-28-31)34-20-8-7-18(12-19(20)25)29-23(32)17-6-4-9-26-13-17/h4,6-9,12-15H,5,10-11H2,1-3H3,(H,29,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system


Bioorg Med Chem Lett 18: 1945-51 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV
More data for this
Ligand-Target Pair