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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Monomerid = 50248121   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50248121
PNG
(CHEMBL464409 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=S)c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H21FN6O2S2/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)36-22-8-7-17(13-19(22)28)31-26(35)34-12-11-33(27(34)37)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins...


Bioorg Med Chem Lett 19: 1323-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50248121
PNG
(CHEMBL464409 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=S)c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H21FN6O2S2/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)36-22-8-7-17(13-19(22)28)31-26(35)34-12-11-33(27(34)37)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50248121
PNG
(CHEMBL464409 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=S)c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H21FN6O2S2/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)36-22-8-7-17(13-19(22)28)31-26(35)34-12-11-33(27(34)37)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



MethylGene Inc.

Curated by ChEMBL


Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA


Bioorg Med Chem Lett 19: 1323-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ
More data for this
Ligand-Target Pair