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Found 1 hit Enz. Inhib. hit(s) with Target = 'Cathepsin S' and Monomerid = 50252656   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin S


(Homo sapiens (Human))
BDBM50252656
PNG
(7-(2-cyclohexylethyl)-6-((pyridin-4-yloxy)methyl)-...)
Show SMILES N#Cc1ncc2cc(CSc3ccncc3)n(CCC3CCCCC3)c2n1
Show InChI InChI=1S/C21H23N5S/c22-13-20-24-14-17-12-18(15-27-19-6-9-23-10-7-19)26(21(17)25-20)11-8-16-4-2-1-3-5-16/h6-7,9-10,12,14,16H,1-5,8,11,15H2
PDB
MMDB

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PC cid
PC sid
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Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin S by fluorescence assay


Bioorg Med Chem Lett 18: 3959-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.009
BindingDB Entry DOI: 10.7270/Q23N235B
More data for this
Ligand-Target Pair