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Found 4 Enz. Inhib. hit(s) with Target = 'Caspase-3' and Monomerid = 50273337
TargetCaspase-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50273337((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataIC50:  12.2nMAssay Description:Inhibition of human caspase 3 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50273337((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataIC50:  16.7nMAssay Description:Inhibition of caspase 3 using Ac-DEVD-AFC fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50273337((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataEC50:  930nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50273337((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataEC50:  16.7nMAssay Description:Inhibition of human recombinant caspase 3 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed